High-risk patients who’ve been exposed to TB or recently converted to positive PPD’s need some kind of preventative Rx. This is not the same as the Tx options which the CDC recommends based on standard RIPE-S therapy, however we have some tough choices to make.

ISONIAZID for six months? Hmm. It can cause hepatitis, peripheral neuropathy and a “lupus-like” syndrome.

We can get away with only two months of treatment with AE that are much worse, using Rifampin and Pyrazinamide - where we’ll get red-orange piss, sweat and tears, as well as a potential hepatitis and in exchange for something lupus-like we go “flu-like” for the duration with myalgia and gout possibly too.

Either way it is not a pretty way to spend your time but at least better than taking HAART therapy after a needle stick. Jeez. There has to be a better way on the horizon!